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Spironolactone (aldactone, aldactone) 100 mg, the recommended dose is 50 mg.

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Spironolactone 50 mg pill

Anti-hypertensives Spironolactone can potentiate the effect of antihypertensive agents. Patients who do not tolerate 25 mg once daily may have their dose reduced to 25 mg every other day. Spironolactone should not be used during breast-feeding. The tablet may be ground or crushed and then suspended in water to make it easier to take.

Daily dosages in excess of mg should be given in several divided doses. Oedema associated with congestive heart failure For management of oedema an initial daily dose of mg of spironolactone administered in either single or divided doses is recommended, but may range from 25 to mg daily or http.

Caution is required, in particular in renal dysfunction.

Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Daily dosages in excess of mg should be given in several divided doses. The Elderly It is recommended that treatment is started spironolactone 50 mg pill the lowest possible dose, then titrated with higher doses until the optimum effect is achieved.

The use of ACE inhibitors in combination with spironolactone may be accompanied by hyperkalaemia, especially in patients with impaired renal function.

Patients who do not tolerate 25 mg once daily may have their dose reduced to 25 mg every other day. Daily dosages in excess of mg should be given in several divided doses.

Name of the medicinal product Spironolactone 50 mg film-coated tablets 2. See Section 4. Dosage should be adjusted on the basis of response and tolerance see sections 4. Fertility Spironolactone may induce impotence and menstrual irregularities see section 4.

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Drug name spironolactone
Active substance aldactone, aldactone
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Increased diuresis has been observed during concomitant use of spironolactone 50 mg pill and heparin. Paediatric population Potassium-sparing diuretics should be used with caution in hypertensive paediatric patients with mild renal insufficiency because lipitor discount prices the risk of hyperkalaemia. If surgery is not an option, this dose is often sufficient to maintain blood pressure and potassium concentration at normal levels.

Maintenance dose should be individually determined.

Digoxin Spironolactone has been shown to increase the half-life of digoxin. Alcohol, barbiturates or narcotics Potentiation of orthostatic hypotension may occur.

The use of ACE inhibitors in combination with spironolactone may be spironolactone 50 mg pill by hyperkalaemia, especially in patients with impaired renal function. Spironolactone has not been shown to be anti-inflammatory, nor to affect the basic pathological process. There is limited paediatric data available see sections 5.

If surgery is not cheap accutane option, this dose is often sufficient to maintain blood pressure and potassium concentration at normal levels.

Paediatric population Initial daily dosage should provide mg of spironolactone per kilogram body weight, given in divided doses. There is limited paediatric data available see sections 5. Spironolactone 50 mg pill who tolerate 25 mg once daily may have their dose increased to 50 mg once daily as clinically indicated. ECG changes may be the first sign of disturbed potassium balance, although hyperkalaemia is not always accompanied by an abnormal ECG.

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Lactose This medicine contains lactose. ECG changes may be the first sign of disturbed potassium balance, although hyperkalaemia is not always accompanied by an abnormal ECG. Method of administration The tablets should be taken with meals. Lithium Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

If surgery is not an option, this dose is often sufficient to maintain blood pressure and potassium concentration at normal levels. Carcinogenicity Animal studies have shown that at high doses and after long-term use, spironolactone induces tumours. Daily dosages in excess of mg should be given in several divided doses.

Spironolactone should not be used during breast-feeding. Cholestyramine Hyperchloremic metabolic acidosis, frequently associated with hyperkalemia, has been reported in patients given spironolactone concurrently with cholestyramine.

Spironolactone has not been shown to be anti-inflammatory, nor to affect the basic pathological process. Oedema associated with congestive heart failure For management of oedema an initial daily dose of mg of spironolactone administered in either single or divided doses is recommended, but may range from 25 to mg daily.

Spironolactone 50 mg pill
Experimental animal studies have shown reproductive toxicity associated with the anti-androgenic effect of spironolactone see section 5 Lithium Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity Oedema associated with congestive heart failure For management of oedema an initial daily dose of mg of spironolactone administered in either single or divided doses is recommended Undesirable effects such as dizziness The significance of these data for clinical application is unclear
In the event of rapid onset of a strong diuretic and antihypertensive effect Method of administration The tablets should be taken with meals Concomitant use of spironolactone with heparin or low molecular weight heparin may lead to severe hyperkalemia Increased diuresis has been observed during concomitant use of spironolactone and heparin Hyperkalaemia may be accompanied by paraesthesia

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Name of the medicinal product Spironolactone 50 mg film-coated tablets 2. Concomitant use requires careful dosing and close monitoring of the electrolyte balance. Heparin, low molecular weight heparin: Lithium Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

Spironolactone and ciclosporin coadministration not recomended, as both increase serum potassium level and possible serious life-threatening interactions. Non-Steroidal Anti-Inflammatory Drugs Acetyl salicylic acid and indomethacin may attenuate the diuretic action of spironolactone due to inhibition of intrarenal synthesis of prostaglandins.

Interactions affecting other medicinal products Anti-coagulants Spironolactone reduces the effect of anticoagulants. This information is intended for use by health professionals 1. Concomitant use of spironolactone with heparin or low molecular weight heparin may lead to severe hyperkalemia. Metabolism and nutrition disorders Very common:

Lithium Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity. The risk of hyperkalaemia increases with decreasing renal function. Undesirable effects such as dizziness, confusion and headache may occur.

  • Diuretics can lead to reduced perfusion of the placenta and thus to impairment of intrauterine growth and are therefore not recommended for the standard therapy for hypertension and edema during pregnancy
  • Fertility Spironolactone may induce impotence and menstrual irregularities see section 4
  • Hyperkalaemia may be accompanied by paraesthesia, weakness, mild paralysis or muscle spasms and is difficult to distinguish clinically from hypokalaemia
  • The dosage of such drugs, in particular ganglion-blocking drugs, can often be halved when spironolactone is added to the therapy

Patients who tolerate 25 mg once daily may have their dose increased to 50 mg once daily as clinically indicated. Breastfeeding Canrenone, the principal and active metabolite of spironolactone, appears in small quantities in human breast milk.

Dosage should be adjusted on the basis of response and tolerance see sections 4. Spironolactone is contraindicated for use in paediatric patients with moderate or severe renal impairment; see section 4.

However, the benefits of therapy should be weighed against the possible long-term harm before initiating long-term use of spironolactone in young patients. Gynaecomastia appears to be doxycycline pharmacy price to both dosage level and duration of therapy and is usually reversible once treatment stops.

Spironolactone is contraindicated for use in paediatric patients with moderate or severe renal impairment; see section 4. Increased diuresis has been observed during concomitant use of spironolactone and heparin. The use of ACE inhibitors in combination with spironolactone may be accompanied by hyperkalaemia, especially in patients with impaired renal function.

Patients who tolerate 25 mg once daily may have their dose increased to 50 mg once daily as clinically indicated. Children should only be treated under guidance of a paediatric specialist.

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Spironolactone, 5 reviews:

Comment №1 about product

Carcinogenicity Animal studies have shown that at high doses and after long-term use, spironolactone induces tumours. Concomitant use of medicinal products known to cause hyperkalaemia with spironolactone may result in severe hyperkalaemia.


4 / 5 stars
Comment №2 about product

Interactions affecting other medicinal products Anti-coagulants Spironolactone reduces the effect of anticoagulants.


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Comment №3 about product

Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

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Comment №4 about product

Concomitant use requires careful dosing and close monitoring of the electrolyte balance. Lactose Each tablet contains mg lactose monohydrate.


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Comment №5 about product

Lithium Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity. Qualitative and quantitative composition Spironolactone 50 mg film-coated tablets contain 50 mg spironolactone Excipients with known effect: Patients who tolerate 25 mg once daily may have their dose increased to 50 mg once daily as clinically indicated.

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